Prof. Dr. Dr. med. Johannes Schödel

Medizin 4

Oberarzt, Facharzt für Innere Medizin und Nephrologie, Zusatzbezeichnung Intensivmedizin, Transplantationsmedizin

Ulmenweg 18
91054 Erlangen

Edificio
Internistisches Zentrum (INZ)

Institutions
Medizin 4

johannes.schoedel(at)uk-erlangen.de

Education, Training and Academic Positions

Publicaciones

Wiegrebe S, Gorski M, Herold JM, Stark KJ, Thorand B, Gieger C, Böger CA, Schödel J, Hartig F, Chen H, Winkler TW, Küchenhoff H, Heid IM: (2024) Analyzing longitudinal trait trajectories using GWAS identifies genetic variants for kidney function decline. Nat Commun. 2024;15(1):
Naas S, Krüger R, Knaup KX, Naas J, Grampp S, Schiffer M, Wiesener M, Schödel J: (2023) Hypoxia controls expression of kidney-pathogenic MUC1 variants. Life Sci Alliance. 2023;6(9):
Grampp S, Kraus A, Skoczynski K, Schiffer M, Krüger R, Naas S, Schödel J, Buchholz B: (2023) Hypoxia induces polycystin-1 expression in the renal epithelium. R Soc Open Sci. 2023;10(5):
Grampp S, Krüger R, Lauer V, Uebel S, Knaup KX, Naas J, Höffken V, Weide T, Schiffer M, Naas S, Schödel J: (2023) Hypoxia hits APOL1 in the kidney. Kidney Int. 2023;104(1): 53-60
Stanzick KJ, Stark KJ, Gorski M, Schödel J, Krüger R, Kronenberg F, Warth R, Heid IM, Winkler TW: (2023) KidneyGPS: a user-friendly web application to help prioritize kidney function genes and variants based on evidence from genome-wide association studies. BMC Bioinformatics. 2023;24(1):
Naas S, Schiffer M, Schödel J: (2023) Hypoxia and renal fibrosis. Am J Physiol Cell Physiol. 2023;325(4): C999-C1016
Koay TW, Schödel J, Hoogewijs D: (2023) CRISPR Activator Approaches to Study Endogenous Androglobin Gene Regulation. Methods Mol Biol. 2023;2648(): 167-185
Protze J, Naas S, Krüger R, Stöhr C, Kraus A, Grampp S, Wiesener M, Schiffer M, Hartmann A, Wullich B, Schödel J: (2022) The renal cancer risk allele at 14q24.2 activates a novel hypoxia-inducible transcription factor-binding enhancer of DPF3 expression. J Biol Chem. 2022;298(3):
Scholz JK, Kraus A, Lüder D, Skoczynski K, Schiffer M, Grampp S, Schödel J, Buchholz B: (2022) Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation. iScience. 2022;25(6):
Koay TW, Osterhof C, Orlando IMC, Keppner A, Andre D, Yousefian S, Alonso MS, Correia M, Markworth R, Schödel J, Hankeln T, Hoogewijs D: (2021) Androglobin gene expression patterns and FOXJ1-dependent regulation indicate its functional association with ciliogenesis. J Biol Chem. 2021;296():
Vonbrunn E, Serikova S, Daniel C, Amann K, Schödel J, Buchholz B, Ferrazzi F, Heller K, Apel H, Büttner-Herold M: (2021) Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA. Front Med (Lausanne). 2021;8():
Lauer V, Grampp S, Platt J, Lafleur V, Lombardi O, Choudhry H, Kranz F, Hartmann A, Wullich B, Yamamoto A, Coleman ML, Ratcliffe PJ, Mole DR, Schödel J: (2020) Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI. J Biol Chem. 2020;295(13): 4065-4078
Orlando IMC, Lafleur VN, Storti F, Spielmann P, Crowther L, Santambrogio S, Schödel J, Hoogewijs D, Mole DR, Wenger RH: (2020) Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression. Haematologica. 2020;105(12): 2774-2784
Wiesener A, Knaup KX, Büttner-Herold M, Dieterle A, Stoeckert J, Riedl B, Morath C, Wald A, Vondran F, Braun F, Schödel J, Schueler M, Schiffer M, Amann K, Reis A, Kraus C, Wiesener MS: (2020) Molecular diagnosis of kidney transplant failure based on urine. Am J Transplant. 2020;20(5): 1410-1416
Safi W, Kraus A, Grampp S, Schödel J, Buchholz B: (2020) Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner. J Mol Med. 2020;98(11): 1547-1559
Fandrey J, Schödel J, Eckardt KU, Katschinski DM, Wenger RH: (2019) Now a Nobel gas: oxygen. Pflugers Arch. 2019;471(11-12): 1343-1358
Schödel J, Ratcliffe PJ: (2019) Mechanisms of hypoxia signalling: new implications for nephrology. Nat Rev Nephrol. 2019;15(10): 641-659
Schmidt-Lauber C, Anneken L, Schödel J: (2019) Hypercalcemia mimicking myocardial infarction. Kidney Int. 2019;96(6): 1428-1428
Grampp S, Schmid V, Salama R, Lauer V, Kranz F, Platt JL, Smythies J, Choudhry H, Goppelt-Struebe M, Ratcliffe PJ, Mole DR, Schödel J: (2017) Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway. PLoS Genet. 2017;13(7): e1006872
Berner D, Zenkel M, Pasutto F, Hoja U, Liravi P, Gusek-Schneider GC, Kruse FE, Schödel J, Reis A, Schlötzer-Schrehardt U: (2017) Posttranscriptional Regulation of LOXL1 Expression Via Alternative Splicing and Nonsense-Mediated mRNA Decay as an Adaptive Stress Response. Invest Ophthalmol Vis Sci. 2017;58(13): 5930-5940
Pasutto F, Zenkel M, Hoja U, Berner D, Uebe S, Ferrazzi F, Schödel J, Liravi P, Ozaki M, Paoli D, Frezzotti P, Mizoguchi T, Nakano S, Kubota T, Manabe S, Salvi E, Manunta P, Cusi D, Gieger C, Wichmann HE, Aung T, Khor CC, Kruse FE, Reis A, Schlötzer-Schrehardt U: (2017) Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1. Nat Commun. 2017;8(): 15466
Lauer V, Schödel J: (2016) Hypoxia-inducible Factor Crosses the Checkpoint. Eur Urol. 2016;70(4): 633-634
Kraus A, Grampp S, Goppelt-Struebe M, Schreiber R, Kunzelmann K, Peters DJ, Leipziger J, Schley G, Schödel J, Eckardt KU, Buchholz B: (2016) P2Y2R is a direct target of HIF-1? and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells. Purinergic Signal. 2016;12(4): 687-695
Grampp S, Platt JL, Lauer V, Salama R, Kranz F, Neumann VK, Wach S, Stöhr C, Hartmann A, Eckardt KU, Ratcliffe PJ, Mole DR, Schödel J: (2016) Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer Nat Commun. 2016;7(): 13183-
Jantsch J, Schödel J: (2015) Hypoxia and hypoxia-inducible factors in myeloid cell-driven host defense and tissue homeostasis. Immunobiology. 2015;220(2): 305-314
Siegert I, Schödel J, Nairz M, Schatz V, Dettmer K, Dick C, Kalucka J, Franke K, Ehrenschwender M, Schley G, Beneke A, Sutter J, Moll M, Hellerbrand C, Wielockx B, Katschinski DM, Lang R, Galy B, Hentze MW, Koivunen P, Oefner PJ, Bogdan C, Weiss G, Willam C, Jantsch J: (2015) Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1? upon LPS Activation in the Presence of Ample Oxygen. Cell Rep. 2015;13(10): 2048-55
Schörg A, Santambrogio S, Platt JL, Schödel J, Lindenmeyer MT, Cohen CD, Schrödter K, Mole DR, Wenger RH, Hoogewijs D: (2015) Destruction of a distal hypoxia response element abolishes trans-activation of the PAG1 gene mediated by HIF-independent chromatin looping. Nucleic Acids Res. 2015;43(12): 5810-23
Choudhry H, Albukhari A, Morotti M, Haider S, Moralli D, Smythies J, Schödel J, Green CM, Camps C, Buffa F, Ratcliffe P, Ragoussis J, Harris AL, Mole DR: (2015) Tumor hypoxia induces nuclear paraspeckle formation through HIF-2? dependent transcriptional activation of NEAT1 leading to cancer cell survival. Oncogene. 2015;34(34): 4482-90
Choudhry H, Schödel J, Oikonomopoulos S, Camps C, Grampp S, Harris AL, Ratcliffe PJ, Ragoussis J, Mole DR: (2014) Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2. EMBO Rep. 2014;15(1): 70-6
Feng T, Yamamoto A, Wilkins SE, Sokolova E, Yates LA, Münzel M, Singh P, Hopkinson RJ, Fischer R, Cockman ME, Shelley J, Trudgian DC, Schödel J, McCullagh JS, Ge W, Kessler BM, Gilbert RJ, Frolova LY, Alkalaeva E, Ratcliffe PJ, Schofield CJ, Coleman ML: (2014) Optimal translational termination requires C4 lysyl hydroxylation of eRF1. Mol Cell. 2014;53(4): 645-54
Grampp S, Goppelt-Strübe M, Eckardt KU, Schödel J: (2014) ANALYSES OF HYPOXIA INDUCIBLE TRANSCRIPTION FACTOR DNA-BINDING AND HYPOXIC GENE REGULATION IN PRIMARY HUMAN RENAL TUBULAR CELLS Nephrol Dial Transplant. 2014;29 3(): 330-330
Schley G, Klanke B, Schödel J, Kröning S, Türkoglu G, Beyer A, Hagos Y, Amann K, Burckhardt BC, Burzlaff N, Eckardt KU, Willam C: (2012) Selective stabilization of HIF-1? in renal tubular cells by 2-oxoglutarate analogues. Am J Pathol. 2012;181(5): 1595-606
Schietke RE, Hackenbeck T, Tran M, Günther R, Klanke B, Warnecke CL, Knaup KX, Shukla D, Rosenberger C, Koesters R, Bachmann S, Betz P, Schley G, Schödel J, Willam C, Winkler T, Amann K, Eckardt KU, Maxwell P, Wiesener MS: (2012) Renal Tubular HIF-2? Expression Requires VHL Inactivation and Causes Fibrosis and Cysts. PLoS ONE. 2012;7(1): e31034
Jantsch J, Wiese M, Schödel J, Castiglione K, Gläsner J, Kolbe S, Mole D, Schleicher U, Eckardt KU, Hensel M, Lang R, Bogdan C, Schnare M, Willam C: (2011) Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1? (HIF1A) and result in differential HIF1A-dependent gene expression. J Leukoc Biol. 2011;90(3): 551-62
Schley G, Klanke B, Schödel J, Forstreuter F, Shukla D, Kurtz A, Amann K, Wiesener MS, Rosen S, Eckardt KU, Maxwell PH, Willam C: (2011) Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury. J Am Soc Nephrol. 2011;22(11): 2004-15
Schietke RE, Warnecke C, Wacker I, Schödel J, Mole DR, Câmpean V, Amann K, Goppelt-Struebe M, Behrens J, Eckardt KU, Wiesener MS: (2010) The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1. J Biol Chem. 2010;285(9): 6658-69
Gimm T, Wiese M, Teschemacher B, Deggerich A, Schödel J, Knaup KX, Hackenbeck T, Hellerbrand C, Amann K, Wiesener MS, Höning S, Eckardt KU, Warnecke C: (2010) Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. FASEB J. 2010;24(11): 4443-58
Schödel J, Bohr D, Klanke B, Schley G, Schlotzer-Schrehardt U, Warnecke C, Kurtz A, Amann K, Eckardt KU, Willam C: (2010) Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells. Kidney Int. 2010;78(9): 857-67
Hackenbeck T, Knaup KX, Schietke R, Schödel J, Willam C, Wu X, Warnecke C, Eckardt KU, Wiesener MS: (2009) HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia. Cell Cycle. 2009;8(9): 1386-95
Schödel J, Klanke B, Weidemann A, Buchholz B, Bernhardt W, Bertog M, Amann K, Korbmacher C, Wiesener M, Warnecke C, Kurtz A, Eckardt KU, Willam C: (2009) HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Am J Pathol. 2009;174(5): 1663-74
Bernhardt WM, Gottmann U, Doyon F, Buchholz B, Câmpean V, Schödel J, Reisenbuechler A, Klaus S, Arend M, Flippin L, Willam C, Wiesener MS, Yard B, Warnecke C, Eckardt KU: (2009) Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model. Proc Natl Acad Sci U S A. 2009;106(50): 21276-81