Medizin 4
Prof. Dr. med. Carsten Willam
Leitender Oberarzt, Facharzt für Innere Medizin, Nephrologie und Intensivmedizin, Rettungsmediziner
Ulmenweg 18
91054 Erlangen
Edificio
Internistisches Zentrum (INZ)
Institutions
Medizin 4
Education, Training and Academic Positions
Publicaciones
- (2024) [The ROSE concept: modern fluid management in intensive care medicine]. Med Klin Intensivmed Notfmed. 2024;119(8): 634-639
- (2024) [Clinical acute and emergency medicine curriculum-focus on internal medicine : Recommendations for advanced training in internal medicine in the emergency department]. Med Klin Intensivmed Notfmed. 2024;119(Suppl 1): 1-50
- (2024) Therapeutic relevance - Influence of AKI on Intensive Care Medicine therapy Nephrologie. 2024;19(3): 135-144
- (2024) Lymphocyte Immune Assays for the Management of Immunosuppression of Kidney Transplant Patients in Sepsis J Am Soc Nephrol. 2024;35 Suppl S(10):
- (2024) Safety and Efficiency Evaluation of Carbon Dioxide Removal in Combination with Continuous Veno-Venous Hemodialysis/Hemodiafiltration Therapy: Baseline Characteristics of the multiECCO2R Study J Am Soc Nephrol. 2024;35 Suppl S(10):
- (2023) Fatal Puumala Hantavirus Infection in a Patient with Common Variable Immunodeficiency (CVID). Microorganisms. 2023;11(2):
- (2023) EXCHANGE-2: investigating the efficacy of add-on plasma exchange as an adjunctive strategy against septic shock-a study protocol for a randomized, prospective, multicenter, open-label, controlled, parallel-group trial. Trials. 2023;24(1):
- (2023) β-(1→3)-D-glucan- and mannan-guided early termination of antifungal therapy in ICU patients: a randomized controlled study. Antimicrob Agents Chemother. 2023;67(11):
- (2023) No benefit of HIF prolyl hydroxylase inhibition for hypertensive renal damage in renovascular hypertensive rats. Front Physiol. 2023;14():
- (2023) Reconfiguration and loss of peritubular capillaries in chronic kidney disease. Sci Rep. 2023;13(1):
- (2023) [Adsorbers and their evidence]. Anaesthesiologie. 2023;72(12): 841-842
- (2023) [Measures and Recommendations for Ensuring Adequate Inpatient Care Capacities for Pandemic Management within a Region: Results of a Hybrid Delphi Method]. Gesundheitswesen. 2023;85(12): 1173-1182
- (2022) The Effect of Filter Lifespan during Continuous Renal Replacement Therapy in Critically Ill Patients with Acute Kidney Injury on the Rate of New-Onset Infection: Analysis from the RICH Randomized Controlled Trial. Am J Respir Crit Care Med. 2022;206(4): 511-514
- (2022) Present practise patterns of renal replacement therapy in German intensive care medicine. Med Klin Intensivmed Notfmed. 2022;117(5): 367-373
- (2021) [Core curriculum Medical intensive care medicine of the German Society of Medical Intensive Care and Emergency Medicine (DGIIN)]. Med Klin Intensivmed Notfmed. 2021;116(Suppl 1): 1-45
- (2021) ["Intravascular space contracted-tissue space expanded": interstitial edema and fluid management in intensive care medicine]. Med Klin Intensivmed Notfmed. 2021;116(8): 665-671
- (2021) Successful treatment of COVID-19 infection with convalescent plasma in B-cell-depleted patients may promote cellular immunity. Eur J Immunol. 2021;51(10): 2478-2484
- (2021) Inhibition of transforming growth factor β1 signaling in resident interstitial cells attenuates profibrotic gene expression and preserves erythropoietin production during experimental kidney fibrosis in mice. Kidney Int. 2021;100(1): 122-137
- (2021) [Intravenous fluid therapy and acute kidney injury - What's new?] Dtsch Med Wochenschr. 2021;146(15): 977-981
- (2021) [Fluid management in emergency and intensive care medicine]. Med Klin Intensivmed Notfmed. 2021;116(8): 635-635
- (2021) Is COVID-19-associated pulmonary aspergillosis (CAPA) a myth? Frequency of Aspergillus detection from respiratory samples in intensive care unit patients with and without COVID-19 Mycoses. 2021;64 Suppl 1(): 3-3
- (2020) [Quality improvement measures in the care of critically ill intensive care patients with renal replacement therapy for acute kidney injury : Position paper of the Kidney Section of DIVI in collaboration with DGAI and DGIIN]. Med Klin Intensivmed Notfmed. 2020;115(7): 566-570
- (2020) Disseminated Multifocal Intracerebral Bleeding Events in Three Coronavirus Disease 2019 Patients on Extracorporeal Membrane Oxygenation As Rescue Therapy. Crit Care Explor. 2020;2(9):
- (2020) CytoResc - "CytoSorb" Rescue for critically ill patients undergoing the COVID-19 Cytokine Storm: A structured summary of a study protocol for a randomized controlled trial. Trials. 2020;21(1): 577
- (2019) A Fluorescent Benzo[g]isoquinoline-Based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging. ChemMedChem. 2019;14(1): 94-99
- (2019) Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis. Kidney Int. 2019;96(2): 378-396
- (2019) Correction: Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology. PLoS ONE. 2019;14(6):
- (2018) Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology. PLoS ONE. 2018;13(7):
- (2018) [Dose adjustment of anti-infective drugs in patients with renal failure and renal replacement therapy in intensive care medicine : Recommendations from the renal section of the DGIIN, ÖGIAIN and DIVI]. Med Klin Intensivmed Notfmed. 2018;113(5): 384-392
- (2018) [Extracorporeal renal replacement therapy in acute kidney injury : Recommendations from the renal section of the DGIIN, ÖGIAIN and DIVI]. Med Klin Intensivmed Notfmed. 2018;113(5): 370-376
- (2018) [Metabolic management and nutrition in critically ill patients with renal dysfunction : Recommendations from the renal section of the DGIIN, ÖGIAIN, and DIVI]. Med Klin Intensivmed Notfmed. 2018;113(5): 393-400
- (2018) [Prevention of acute kidney injury in critically ill patients : Recommendations from the renal section of the DGIIN, ÖGIAIN and DIVI]. Med Klin Intensivmed Notfmed. 2018;113(5): 358-369
- (2018) [Regional citrate anticoagulation in renal replacement therapy in the intensive care station : Recommendations from the renal section of the DGIIN, ÖGIAIN and DIVI]. Med Klin Intensivmed Notfmed. 2018;113(5): 377-383
- (2018) HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease. Kidney Int. 2018;94(5): 887-899
- (2017) Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease. Kidney Int. 2017;91(3): 616-627
- (2017) Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development. Am J Pathol. 2017;187(7): 1496-1511
- (2016) Erythropoietin production by PDGFR-?(+) cells. Pflugers Arch. 2016;468(8): 1479-87
- (2016) Effects of linagliptin on renal endothelial function in patients with type 2 diabetes: a randomised clinical trial. Diabetologia. 2016;59(12): 2579-2587
- (2016) Myeloid Cell-Derived HIF-1? Promotes Control of Leishmania major. J Immunol. 2016;197(10): 4034-4041
- (2015) Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult Acta Physiol (Oxf). 2015;213 699(): 79-80
- (2015) [Lung and kidney failure : Pathogenesis, interactions, and therapy]. Med Klin Intensivmed Notfmed. 2015;110(6): 452-8
- (2015) Kidney injury is independent of endothelial HIF-1?. J Mol Med. 2015;93(8): 891-904
- (2015) Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult. Pflugers Arch. 2015;467(10): 2141-9
- (2015) Identification of Plasma Metabolites Prognostic of Acute Kidney Injury after Cardiac Surgery with Cardiopulmonary Bypass. J Proteome Res. 2015;14(7): 2897-905
- (2015) Hypoxia inhibits nephrogenesis through paracrine Vegfa despite the ability to enhance tubulogenesis. Kidney Int. 2015;88(6): 1283-1292
- (2015) Comparison of Plasma and Urine Biomarker Performance in Acute Kidney Injury. PLoS ONE. 2015;10(12): e0145042
- (2015) Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1? upon LPS Activation in the Presence of Ample Oxygen. Cell Rep. 2015;13(10): 2048-55
- (2015) The Isoquinolone Derived Prolyl Hydroxylase Inhibitor ICA Is a Potent Substrate of the Organic Anion Transporters 1 and 3. Nephron. 2015;131(4): 285-9
- (2014) The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity. J Biol Chem. 2014;289(6): 3339-51
- (2014) HIF meets NF-?B signaling. Kidney Int. 2014;85(2): 232-4
- (2014) Hypoxia-Inducible Factor-1? Causes Renal Cyst Expansion through Calcium-Activated Chloride Secretion. J Am Soc Nephrol. 2014;25(3): 465-74
- (2013) HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. Blood. 2013;121(26): 5158-66
- (2013) Deletion of von Hippel-Lindau protein converts renin-producing cells into erythropoietin-producing cells. J Am Soc Nephrol. 2013;24(3): 433-44
- (2013) Low-flow CO2 removal integrated into a renal-replacement circuit can reduce acidosis and decrease vasopressor requirements. Crit Care. 2013;17(4): R154
- (2012) Selective stabilization of HIF-1? in renal tubular cells by 2-oxoglutarate analogues. Am J Pathol. 2012;181(5): 1595-606
- (2012) The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment. Nephrol Dial Transplant. 2012;27(3): 929-36
- (2012) Renal Tubular HIF-2? Expression Requires VHL Inactivation and Causes Fibrosis and Cysts. PLoS ONE. 2012;7(1): e31034
- (2011) Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. J Biol Chem. 2011;286(15): 13041-51
- (2011) [Calciphylaxis : A less well-known, clinically relevant disease.] Pathologe. 2011;32(3): 250-256
- (2011) Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1? (HIF1A) and result in differential HIF1A-dependent gene expression. J Leukoc Biol. 2011;90(3): 551-62
- (2011) Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury. J Am Soc Nephrol. 2011;22(11): 2004-15
- (2010) Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells. Kidney Int. 2010;78(9): 857-67
- (2009) HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia. Cell Cycle. 2009;8(9): 1386-95
- (2009) HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Am J Pathol. 2009;174(5): 1663-74
- (2009) Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model. Proc Natl Acad Sci U S A. 2009;106(50): 21276-81
- (2008) HIF activation protects from acute kidney injury. J Am Soc Nephrol. 2008;19(3): 486-94
- (2008) Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet. 2008;40(2): 170-80
- (2008) Hypoxia and Hypoxia-Inducible Factor-1{alpha} Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function. J Immunol. 2008;180(7): 4697-705
- (2008) The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors. Exp Cell Res. 2008;314(10): 2016-27
- (2008) Small interfering RNA (siRNA) delivery into murine bone marrow-derived dendritic cells by electroporation. J Immunol Methods. 2008;337(1): 71-77
- (2008) Hypoxia, via stabilization of the hypoxia-inducible factor HIF-1alpha, is a direct and sufficient stimulus for brain-type natriuretic peptide induction. Biochem J. 2008;409(1): 233-42
- (2007) Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. Am J Pathol. 2007;170(3): 830-42
- (2007) Hypoxia-inducible transcription factors and their role in renal disease. Semin Nephrol. 2007;27(3): 363-72
- (2007) Transvenous renal biopsy of a kidney transplant in a patient with a suspected bleeding disorder. Am J Transplant. 2007;7(8): 2052-3
- (2007) Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia. Int J Cancer. 2007;121(11): 2434-42
- (2007) The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney. Am J Pathol. 2007;171(5): 1483-98
- (2007) Organ protection by hypoxia and hypoxia-inducible factors. Methods Enzymol. 2007;435(): 219-45
- (2006) Inconsistent effects of acidosis on HIF-alpha protein and its target genes. Pflugers Arch. 2006;451(4): 534-43
- (2006) Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. J Am Soc Nephrol. 2006;17(7): 1970-8
- (2006) HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. J Mol Cell Cardiol. 2006;41(1): 68-77
- (2006) Expression of hypoxia-inducible transcription factors in developing human and rat kidneys. Kidney Int. 2006;69(1): 114-22
- (2005) Role of hypoxia in the pathogenesis of renal disease Kidney Int. 2005;68 Suppl. (): 46-51
- (2005) Role of hypoxia in the pathogenesis of renal disease. Kidney Int Suppl. 2005;(99): S46-51
- (2005) Preconditional induction of HIF by carbon monoxide ameliorates ischemic acute renal failure Nephrol Dial Transplant. 2005;20 Suppl.(): V54-V54
- (2003) Activation of the hypoxia-inducible factor-pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors. FASEB J. 2003;17(9): 1186-8
- (2002) Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis. Proc Natl Acad Sci U S A. 2002;99(16): 10423-8
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