PD Dr. med. Gunnar Schley
Oberarzt, Facharzt für Innere Medizin und Nephrologie
Institutions
Medizin 4
Education, Training and Academic Positions
Publications
- (2023)No benefit of HIF prolyl hydroxylase inhibition for hypertensive renal damage in renovascular hypertensive rats.Front Physiol. 2023;14():
- (2023)Reconfiguration and loss of peritubular capillaries in chronic kidney disease.Sci Rep. 2023;13(1):
- (2023)Strikingly conserved gene expression changes of polyamine regulating enzymes among various forms of acute and chronic kidney injury.Kidney Int. 2023;104(1): 90-107
- (2022)The prolyl hydroxylase inhibitor molidustat fails to restore erythropoietin production in the fibrotic kidney.Acta Physiol (Oxf). 2022;235(4):
- (2022)A PHD inhibitor prevents changes in the phosphoproteome and capillary rarefaction by CsA: treatment option for CKD?Kidney Int. 2022;102(4): 686-688
- (2022)Prolyl-4-hydroxylases 2 and 3 control erythropoietin production in renin-expressing cells of mouse kidneys.J Physiol. 2022;600(3): 671-694
- (2021)["Intravascular space contracted-tissue space expanded": interstitial edema and fluid management in intensive care medicine].Med Klin Intensivmed Notfmed. 2021;116(8): 665-671
- (2021)[Intravenous fluid therapy and acute kidney injury - What's new?]Dtsch Med Wochenschr. 2021;146(15): 977-981
- (2020)Inhibition of oxygen-sensing prolyl hydroxylases increases lipid accumulation in human primary tubular epithelial cells without inducing ER stress.Cell Tissue Res. 2020;381(1): 125-140
- (2020)Soluble Urokinase Receptor and Acute Kidney Injury.N Engl J Med. 2020;382(22):
- (2019)A Fluorescent Benzo[g]isoquinoline-Based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging.ChemMedChem. 2019;14(1): 94-99
- (2019)Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis.Kidney Int. 2019;96(2): 378-396
- (2019)Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A.J Am Soc Nephrol. 2019;30(2): 228-242
- (2019)Correction: Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology.PLoS ONE. 2019;14(6):
- (2019)Extracellular DNA traps in inflammation, injury and healing.Nat Rev Nephrol. 2019;15(9): 559-575
- (2018)Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology.PLoS ONE. 2018;13(7):
- (2018)HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease.Kidney Int. 2018;94(5): 887-899
- (2016)Glucose promotes secretion-dependent renal cyst growth.J Mol Med. 2016;94(1): 107-17
- (2016)The impact of hypoxia on nephrogenesis.Curr Opin Nephrol Hypertens. 2016;25(3): 180-6
- (2016)P2Y2R is a direct target of HIF-1? and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells.Purinergic Signal. 2016;12(4): 687-695
- (2016)Myeloid Cell-Derived HIF-1? Promotes Control of Leishmania major.J Immunol. 2016;197(10): 4034-4041
- (2015)Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insultActa Physiol (Oxf). 2015;213 699(): 79-80
- (2015)Kidney injury is independent of endothelial HIF-1?.J Mol Med. 2015;93(8): 891-904
- (2015)Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult.Pflugers Arch. 2015;467(10): 2141-9
- (2015)Identification of Plasma Metabolites Prognostic of Acute Kidney Injury after Cardiac Surgery with Cardiopulmonary Bypass.J Proteome Res. 2015;14(7): 2897-905
- (2015)Hypoxia inhibits nephrogenesis through paracrine Vegfa despite the ability to enhance tubulogenesis.Kidney Int. 2015;88(6): 1283-1292
- (2015)Comparison of Plasma and Urine Biomarker Performance in Acute Kidney Injury.PLoS ONE. 2015;10(12): e0145042
- (2015)Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1? upon LPS Activation in the Presence of Ample Oxygen.Cell Rep. 2015;13(10): 2048-55
- (2015)The Isoquinolone Derived Prolyl Hydroxylase Inhibitor ICA Is a Potent Substrate of the Organic Anion Transporters 1 and 3.Nephron. 2015;131(4): 285-9
- (2014)The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity.J Biol Chem. 2014;289(6): 3339-51
- (2014)Hypoxia-Inducible Factor-1? Causes Renal Cyst Expansion through Calcium-Activated Chloride Secretion.J Am Soc Nephrol. 2014;25(3): 465-74
- (2014)Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells.Kidney Int. 2014;85(5): 1058-67
- (2012)Selective stabilization of HIF-1? in renal tubular cells by 2-oxoglutarate analogues.Am J Pathol. 2012;181(5): 1595-606
- (2012)The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment.Nephrol Dial Transplant. 2012;27(3): 929-36
- (2012)Renal Tubular HIF-2? Expression Requires VHL Inactivation and Causes Fibrosis and Cysts.PLoS ONE. 2012;7(1): e31034
- (2011)Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion.J Mol Med. 2011;89(3): 251-61
- (2011)The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis.Nephrol Dial Transplant. 2011;26(11): 3458-65
- (2011)Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury.J Am Soc Nephrol. 2011;22(11): 2004-15
- (2010)Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells.Kidney Int. 2010;78(9): 857-67
- (2009)Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors.PLoS ONE. 2009;4(11): e7875
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