Prof. Dr. med. Björn Buchholz

Medizin 4

Transplantationszentrum

Prof. Dr. med. Björn Buchholz

Oberarzt, Facharzt für Innere Medizin und Nephrologie

Ulmenweg 18, 91054 Erlangen

Institutions
Medizin 4
Transplantationszentrum

bjoern.buchholz(at)uk-erlangen.de

Education, Training and Academic Positions

Publications

Gluais Dagorn P, Buchholz B, Kraus A, Batchuluun B, Bange H, Blockken L, Steinberg GR, Moller DE, Hallakou-Bozec S: (2023) A novel direct adenosine monophosphate kinase activator ameliorates disease progression in preclinical models of Autosomal Dominant Polycystic Kidney Disease. Kidney Int. 2023;103(5): 917-929
Scholz JK, Kraus A, Lüder D, Skoczynski K, Schiffer M, Grampp S, Schödel J, Buchholz B: (2022) Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation. iScience. 2022;25(6):
Dagorn PG, Buchholz B, Bange H, Blockken L, Moller DE, Hallakou-Bozec S: (2022) PRECLINICAL EFFICACY OF DIRECT AMPK ACTIVATION WITH A NOVEL SMALL MOLECULE-PXL770-FOR THE TREATMENT OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE Nephrol Dial Transplant. 2022;37 Suppl 3(): I9-I9
Bichlmayer EM, Mahl L, Hesse L, Pion E, Haller V, Moehwald A, Hackl C, Werner JM, Schlitt HJ, Schwarz S, Kainz P, Brochhausen C, Groeger C, Steger F, Kölbl O, Daniel C, Amann K, Kraus A, Buchholz B, Aung T, Haerteis S: (2022) A 3D In Vivo Model for Studying Human Renal Cystic Tissue and Mouse Kidney Slices. Cells. 2022;11(15):
Talbi K, Cabrita I, Kraus A, Hofmann S, Skoczynski K, Kunzelmann K, Buchholz B, Schreiber R: (2021) The chloride channel CFTR is not required for cyst growth in an ADPKD mouse model. FASEB J. 2021;35(10):
Vonbrunn E, Serikova S, Daniel C, Amann K, Schödel J, Buchholz B, Ferrazzi F, Heller K, Apel H, Büttner-Herold M: (2021) Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA. Front Med (Lausanne). 2021;8():
Burgmaier K, Kilian S, Arbeiter K, Atmis B, Büscher A, Derichs U, Dursun I, Duzova A, Eid LA, Galiano M, Gessner M, Gokce I, Haeffner K, Hooman N, Jankauskiene A, Körber F, Longo G, Massella L, Mekahli D, Miloševski-Lomić G, Nalcacioglu H, Rus R, Shroff R, Stabouli S, Weber LT, Wygoda S, Yilmaz A, Zachwieja K, Zagozdzon I, Dötsch J, Schaefer F, Liebau MC, ARegPKD Consortium , Burgmaier K, Kilian S, Arbeiter K, Atmis B, Büscher A, Derichs U, Dursun I, Duzova A, Eid LA, Galiano M, Gessner M, Gokce I, Haeffner K, Hooman N, Jankauskiene A, Longo G, Massella L, Mekahli D, Miloševski-Lomić G, Nalcacioglu H, Rus R, Shroff R, Stabouli S, Weber LT, Wygoda S, Yilmaz A, Zachwieja K, Zagozdzon I, Dötsch J, Schaefer F, Liebau MC, Potemkina A, Ranguelov N, Collard L, De Mul A, Feldkoetter M, Seeman T, Zieg J, Thumfart J, Grundmann F, Buchholz B, Pape L, Gross O, Patzer L, Schild R, Haffner D, Bernhardt W, Wuehl E, Henn M, Halbritter J, Klaus G, Lechner F, Lange-Sperandio B, Uetz B, Benz M, König J, Staude H, Wurm D, Bald M, Soliman NA, Ariceta G, Rodriguez JDG, de la Cerda Ojeda F, Harambat J, Ranchin B, Fila M, Dossier C, Boyer O, Marlais M, Papachristou F, Mencarelli F, Mastrangelo A, Murer L, Emma F, Ruzgiene D, Taranta-Janusz K, Balasz-Chmielewska I, Miklaszewska M, Stanczyk M, Sikora P, Kowalewska C, Szczepanska M, Teixeira A, Dunand O, Rachisan A, Paripović D, Prikhodina L, Jilani H, Bayazit AK, Soylu A, Candan C, Sever L, Emre S, Cicek N, Akinci N, Mir S, Poyrazoğlu HM, Tabel Y, Nalcacioglu H: (2021) Early childhood height-adjusted total kidney volume as a risk marker of kidney survival in ARPKD. Sci Rep. 2021;11(1):
Herden U, Sterneck M, Li J, Achilles E, Buchholz B, Fischer L: (2020) SINGLE CENTER, OPEN-LABEL, RANDOMIZED, CONTROLLED, CROSS OVER STUDY TO EVALUATE THE PHARMACOKINETIC AND BIOAVAILABILITY OF ENVARSUS (R) IN COMPARISON TO ADVAGRAF (R) IN DE NOVO LIVER TRANSPLANT RECIPIENTS Transpl Int. 2020;33 Suppl 2(): 19-19
Nunius C, Büttner-Herold M, Bertz S, Schiffer M, Buchholz B: (2020) Isolated thrombotic microangiopathy of the small intestine in a patient with atypical hemolytic uremic syndrome - a case report. BMC Nephrol. 2020;21(1):
Cabrita I, Kraus A, Scholz JK, Skoczynski K, Schreiber R, Kunzelmann K, Buchholz B: (2020) Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo. Nat Commun. 2020;11(1):
Safi W, Kraus A, Grampp S, Schödel J, Buchholz B: (2020) Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner. J Mol Med. 2020;98(11): 1547-1559
Buchholz B, Eckardt KU: (2020) Role of oxygen and the HIF-pathway in polycystic kidney disease. Cell Signal. 2020;69():
Cabrita I, Buchholz B, Schreiber R, Kunzelmann K: (2020) TMEM16A drives renal cyst growth by augmenting Ca2+ signaling in M1 cells. J Mol Med. 2020;98(5): 659-671
Burgmaier K, Ariceta G, Bald M, Buescher AK, Burgmaier M, Erger F, Gessner M, Gokce I, König J, Kowalewska C, Massella L, Mastrangelo A, Mekahli D, Pape L, Patzer L, Potemkina A, Schalk G, Schild R, Shroff R, Szczepanska M, Taranta-Janusz K, Tkaczyk M, Weber LT, Wühl E, Wurm D, Wygoda S, Zagozdzon I, Dötsch J, Oh J, Schaefer F, Liebau MC, ARegPKD consortium , Eid LA, Arbeiter K, Ranguelov N, Collard L, De Mul A, Feldkoetter M, Seeman T, Thumfart J, Grundmann F, Galiano M, Buchholz B, Buescher R, Häffner K, Gross O, Bernhardt W, Doyon A, Henn M, Halbritter J, Derichs U, Klaus G, Lange-Sperandio B, Uetz B, Benz M, Titieni A, Staude H, Leichter HE, Soliman NA, Lara LE, de la Cerda Ojeda F, Harambat J, Ranchin B, Fila M, Dossier C, Boyer O, Marlais M, Stabouli S, Hooman N, Mencarelli F, Morello W, Longo G, Emma F, Ruzgiene D, Wasilewska A, Balasz-Chmielewska I, Miklaszewska M, Stanczyk M, Sikora P, Litwin M, Morawiec-Knysak A, Teixeira A, Milosevski-Lomic G, Prikhodina L, Rus R, Jilani H, Melek E, Duzova A, Soylu A, Candan C, Sever L, Yilmaz A, Cicek N, Akinci N, Mir S, Dursun I, Tabel Y, Nalcacioglu H: (2020) Severe neurological outcomes after very early bilateral nephrectomies in patients with autosomal recessive polycystic kidney disease (ARPKD). Sci Rep. 2020;10(1):
Mayer M, Fey K, Heinze E, Wick CR, Abboud MI, Yeh TL, Tumber A, Orth N, Schley G, Buchholz B, Clark T, Schofield CJ, Willam C, Burzlaff N: (2019) A Fluorescent Benzo[g]isoquinoline-Based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging. ChemMedChem. 2019;14(1): 94-99
Schreiber R, Buchholz B, Kraus A, Schley G, Scholz J, Ousingsawat J, Kunzelmann K: (2019) Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A. J Am Soc Nephrol. 2019;30(2): 228-242
Burgmaier K, Kunzmann K, Ariceta G, Bergmann C, Buescher AK, Burgmaier M, Dursun I, Duzova A, Eid L, Erger F, Feldkoetter M, Galiano M, Geßner M, Goebel H, Gokce I, Haffner D, Hooman N, Hoppe B, Jankauskiene A, Klaus G, König J, Litwin M, Massella L, Mekahli D, Melek E, Mir S, Pape L, Prikhodina L, Ranchin B, Schild R, Seeman T, Sever L, Shroff R, Soliman NA, Stabouli S, Stanczyk M, Tabel Y, Taranta-Janusz K, Testa S, Thumfart J, Topaloglu R, Weber LT, Wicher D, Wühl E, Wygoda S, Yilmaz A, Zachwieja K, Zagozdzon I, Zerres K, ESCAPE Study Group , GPN Study Group , Dötsch J, Schaefer F, Liebau MC, ARegPKD Consortium , Ranguelov N, Godefroid N, Collard L, Lombet J, Maquet J, Schalk G, Querfeld U, Beck BB, Benzing T, Buettner R, Grundmann F, Kurschat C, Benz K, Tzschoppe A, Buchholz B, Buescher R, Häffner K, Pohl M, Gross O, Krügel J, Stock J, Patzer L, Oh J, Bernhardt W, Doyon A, Vinke T, Sander A, Henn M, Derichs U, Beetz R, Jeck N, Lange-Sperandio B, Ponsel S, Kusser F, Uetz B, Benz M, Schmidt S, Huppertz-Kessler C, Kranz B, Titieni A, Wurm D, Leichter HE, Bald M, Billing H, Nabhan MM, Lara LE, Papachristou F, Emma F, Cerkauskiene R, Azukaitis K, Wasilewska A, Balasz-Chmielewska I, Miklaszewska M, Tkaczyk M, Sikora P, Zaniew M, Niemirska A, Antoniewicz J, Lesiak J, Afonso AC, Teixeira A, Milosevski-Lomic G, Paripović D, Peco-Antic A, Papizh S, Bayazit AK, Anarat A, Soylu A, Kavukcu S, Candan C, Caliskan S, Canpolat N, Emre S, Alpay H, Akinci N, Conkar S, Poyrazoglu HM, Dusunsel R: (2018) Risk Factors for Early Dialysis Dependency in Autosomal Recessive Polycystic Kidney Disease. J Pediatr. 2018;199(): 22-28.e6
Schenk LK, Buchholz B, Henke SF, Michgehl U, Daniel C, Amann K, Kunzelmann K, Pavenstädt HJ: (2018) Nephron-specific knockout of TMEM16A leads to reduced number of glomeruli and albuminuria. Am J Physiol Renal Physiol. 2018;315(6): F1777-F1786
Kraus A, Peters DJM, Klanke B, Weidemann A, Willam C, Schley G, Kunzelmann K, Eckardt KU, Buchholz B: (2018) HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease. Kidney Int. 2018;94(5): 887-899
Schellinger IN, Cordasic N, Panesar J, Buchholz B, Jacobi J, Hartner A, Klanke B, Jakubiczka-Smorag J, Burzlaff N, Heinze E, Warnecke C, Raaz U, Willam C, Tsao PS, Eckardt KU, Amann K, Hilgers KF: (2017) Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease. Kidney Int. 2017;91(3): 616-627
Ebner K, Schaefer F, Liebau MC, ARegPKD Consortium , Eid LA, Ranguelov N, Adams B, van Hoeck K, Raes A, Mekahli D, Collard L, Lombet J, Maquet J, Cachat F, Schalk G, Seeman T, Ortiz Bruechle N, Zerres K, Thumfart J, Briese S, Querfeld U, Hoppe B, Feldkoetter M, Kirschstein M, Gruening G, Beck BB, Benzing T, Buettner R, Dötsch J, Goebel H, Grundmann F, Hero B, Kurschat C, Weber LT, Mayer B, Weber J, Ritter B, Benz K, Galiano M, Tzschoppe A, Buchholz B, Buescher R, Buescher A, Latta K, Häffner K, Pohl M, Gross O, Krügel J, Stock J, Patzer L, Teichler H, Oh J, Schild R, Illig T, Klopp N, Pape L, Wahrendorf S, Bernhardt W, Doyon A, Wuehl E, Vinke T, Sander A, Kunzmann K, Bergmann C, Wygoda S, Henn M, Wiemann D, Blaschke K, Derichs U, Beetz R, Jeck N, Klaus G, Fehrenbach H, Hampel T, Zoetler S, Wallot M, Kyrieleis H, Lange-Sperandio B, Ponsel S, Kusser F, Hoefele J, Uetz B, Benz M, Schmidt S, Huppertz-Kessler C, Kranz B, Koenig J, Titieni A, Boeswald M, Staude H, Jacoby U, Wurm D, Leichter HE, Bald M, Billing H, Gessner M, Beringer O, Ilmoja ML, Soliman NA, Nabhan MM, Ariceta G, Lara LE, Garcia-Gonzalez MA, Diaz-Rodriguez C, Garcia-Vidal M, Ranchin B, Shroff R, Sterenborg R, Davitala T, Papachristou F, Stabouli S, Sallay P, Hooman N, Ardissino G, Testa S, Massella L, Emma F, Jankauskiene A, Cerkauskiene R, Azukaitis K, Bokenkamp A, van Wijk J, Taranta-Janusz K, Wasilewska A, Zagozdzon I, Balasz-Chmielewska I, Miklaszewska M, Zachwieja K, Drozdz D, Tkaczyk M, Stanczyk M, Sikora P, Zaniew M, Litwin M, Niemirska A, Wicher D, Jankowska I, Antoniewicz J, Lesiak J, Lipinski P, Szczepanska M, Adamczyk P, Morawiec-Knysak A, Caldas Afonso A, Teixeira A, Milosevski-Lomic G, Paripović D, Peco-Antic A, Prikhodina L, Papizh S, Bayazit AK, Anarat A, Melek E, Bayrakci US, Kantar A, Cayci S, Baskin UE, Duzova A, Yuzbasioglu A, Soylu A, Kavukcu S, Kalman S, Evrengül H, Yüksel S, Kara A, Gurgoze MK, Candan C, Sever L, Caliskan S, Canpolat N, Emre S, Yilmaz A, Gökce I, Alpay H, Akinci N, Mir S, Sözeri B, Dursun I, Poyrazoglu HM, Dusunsel R, Nalcacioglu H, Ekinci Z, Tabel Y, Delibas A, Övünc Hacihamdioglu D, Guay-Woodford L: (2017) Recent Progress of the ARegPKD Registry Study on Autosomal Recessive Polycystic Kidney Disease. Front Pediatr. 2017;5():
Kraus A, Schley G, Kunzelmann K, Schreiber R, Peters DJ, Stadler R, Eckardt KU, Buchholz B: (2016) Glucose promotes secretion-dependent renal cyst growth. J Mol Med. 2016;94(1): 107-17
Buchholz B, Schley G, Eckardt KU: (2016) The impact of hypoxia on nephrogenesis. Curr Opin Nephrol Hypertens. 2016;25(3): 180-6
Kraus A, Grampp S, Goppelt-Struebe M, Schreiber R, Kunzelmann K, Peters DJ, Leipziger J, Schley G, Schödel J, Eckardt KU, Buchholz B: (2016) P2Y2R is a direct target of HIF-1? and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells. Purinergic Signal. 2016;12(4): 687-695
Schley G, Scholz H, Kraus A, Hackenbeck T, Klanke B, Willam C, Wiesener MS, Heinze E, Burzlaff N, Eckardt KU, Buchholz B: (2015) Hypoxia inhibits nephrogenesis through paracrine Vegfa despite the ability to enhance tubulogenesis. Kidney Int. 2015;88(6): 1283-1292
Forschbach V, Goppelt-Struebe M, Kunzelmann K, Schreiber R, Piedagnel R, Kraus A, Eckardt KU, Buchholz B: (2015) Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation. Cell Death Dis. 2015;6(): e1899
Buchholz B, Schley G, Faria D, Kroening S, Willam C, Schreiber R, Klanke B, Burzlaff N, Jantsch J, Kunzelmann K, Eckardt KU: (2014) Hypoxia-Inducible Factor-1? Causes Renal Cyst Expansion through Calcium-Activated Chloride Secretion. J Am Soc Nephrol. 2014;25(3): 465-74
Buchholz B, Faria D, Schley G, Schreiber R, Eckardt KU, Kunzelmann K: (2014) Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells. Kidney Int. 2014;85(5): 1058-67
Boehlke C, Kotsis F, Buchholz B, Powelske C, Eckardt KU, Walz G, Nitschke R, Kuehn EW: (2013) Kif3a guides microtubular dynamics, migration and lumen formation of MDCK cells. PLoS ONE. 2013;8(5): e62165
Buchholz B, Teschemacher B, Schley G, Schillers H, Eckardt KU: (2011) Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion. J Mol Med. 2011;89(3): 251-61
Buchholz B, Klanke B, Schley G, Bollag G, Tsai J, Kroening S, Yoshihara D, Wallace DP, Kraenzlin B, Gretz N, Hirth P, Eckardt KU, Bernhardt WM: (2011) The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis. Nephrol Dial Transplant. 2011;26(11): 3458-65
Romaker D, Puetz M, Teschner S, Donauer J, Geyer M, Gerke P, Rumberger B, Dworniczak B, Pennekamp P, Buchholz B, Neumann HP, Kumar R, Gloy J, Eckardt KU, Walz G: (2009) Increased expression of secreted frizzled-related protein 4 in polycystic kidneys. J Am Soc Nephrol. 2009;20(1): 48-56
Schödel J, Klanke B, Weidemann A, Buchholz B, Bernhardt W, Bertog M, Amann K, Korbmacher C, Wiesener M, Warnecke C, Kurtz A, Eckardt KU, Willam C: (2009) HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Am J Pathol. 2009;174(5): 1663-74
Bernhardt WM, Gottmann U, Doyon F, Buchholz B, Câmpean V, Schödel J, Reisenbuechler A, Klaus S, Arend M, Flippin L, Willam C, Wiesener MS, Yard B, Warnecke C, Eckardt KU: (2009) Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model. Proc Natl Acad Sci U S A. 2009;106(50): 21276-81
Weidemann A, Bernhardt WM, Klanke B, Daniel C, Buchholz B, Câmpean V, Amann K, Warnecke C, Wiesener MS, Eckardt KU, Willam C: (2008) HIF activation protects from acute kidney injury. J Am Soc Nephrol. 2008;19(3): 486-94
Jantsch J, Chakravortty D, Turza N, Prechtel AT, Buchholz B, Gerlach RG, Volke M, Gläsner J, Warnecke C, Wiesener MS, Eckardt KU, Steinkasserer A, Hensel M, Willam C: (2008) Hypoxia and Hypoxia-Inducible Factor-1{alpha} Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function. J Immunol. 2008;180(7): 4697-705