Hot Topics in Immunomedicine

Conventional mouse models suffer from major shortcomings like irreproducible results rooted in divergent microbiota and the fact that the transition from studies in mice to bedside practice in humans routinely fails. This seminar will be about the wildling mouse model that we have specifically developed to tackle these shortcomings. In preclinical trials, where even non-human primate models failed to predict the human response, wildlings phenocopied humans and could have prevented these tragically failed human trials. Further, the microbiome of wildlings was stable and highly resilient, thereby providing an excellent model for reproducible experimentation.