Prof. Dr. med. Carsten Willam

Medizin 4

Leitender Oberarzt, Facharzt für Innere Medizin, Nephrologie und Intensivmedizin, Rettungsmediziner

Ulmenweg 18
91054 Erlangen

Gebäude
Internistisches Zentrum (INZ)

Einrichtungen
Medizin 4

Lebenslauf, Veröffentlichungen und Auszeichnungen

Publikationen

Willam C, Herbst L:(2024)[The ROSE concept: modern fluid management in intensive care medicine].Med Klin Intensivmed Notfmed. 2024;119(8): 634-639
DGIIN , DGIM , BDI , DGA , DGE , DGVS , DGG , DGHO , DGI , DGK , DGfN , DG f. Pneumologie und Beatmungsmedizin , DG f. Palliativmedizin , DGRh , Busch HJ, Wolfrum S, Michels G, Baumgärtel M, Bodmann KF, Buerke M, Burst V, Enghard P, Ertl G, Fach WA, Hanses F, Heppner HJ, Hermes C, Janssens U, John S, Jung C, Karagiannidis C, Kiehl M, Kluge S, Koch A, Kochanek M, Korsten P, Lepper PM, Merkel M, Müller-Werdan U, Neukirchen M, Pfeil A, Riessen R, Rottbauer W, Schellong S, Scherg A, Sedding D, Singler K, Thieme M, Trautwein C, Willam C, Werdan K:(2024)[Clinical acute and emergency medicine curriculum-focus on internal medicine : Recommendations for advanced training in internal medicine in the emergency department].Med Klin Intensivmed Notfmed. 2024;119(Suppl 1): 1-50
Grampp S, Willam C:(2024)Therapeutic relevance - Influence of AKI on Intensive Care Medicine therapyNephrologie. 2024;19(3): 135-144
Bakhshiyeva E, Kranefuss M, Schiffer M, Willam C, Brox R, Kurzhagen JT:(2024)Lymphocyte Immune Assays for the Management of Immunosuppression of Kidney Transplant Patients in SepsisJ Am Soc Nephrol. 2024;35 Suppl S(10):
Wammi AP, Kluge S, Jarczak D, Willam C, Blaas SH, Ottillinger B, Korolev N, Braun J, Stauss Grabo GM:(2024)Safety and Efficiency Evaluation of Carbon Dioxide Removal in Combination with Continuous Veno-Venous Hemodialysis/Hemodiafiltration Therapy: Baseline Characteristics of the multiECCO2R StudyJ Am Soc Nephrol. 2024;35 Suppl S(10):
Steininger P, Herbst L, Bihlmaier K, Willam C, Körper S, Schrezenmeier H, Klüter H, Pfister F, Amann K, Weiss S, Krüger DH, Zimmermann R, Korn K, Hofmann J, Harrer T:(2023)Fatal Puumala Hantavirus Infection in a Patient with Common Variable Immunodeficiency (CVID).Microorganisms. 2023;11(2):
David S, Bode C, Stahl K, EXCHANGE-2 Study group , Schmidt J, Seeliger B, Pape T, Schmidt B, Hoeper MM, Wedemeyer H, Welte T, Schmidt-Ott K, Wendel Garcia PD, Hofmänner DA, Andermatt R, Schuepbach R, Bankova A, Gillmann HJ, Stueber T, Jung C, Gerdes A, Putensen C, Sauer A, Wild L, Lehmann F, Weigand MA, Nusshag C, Schenz J, Decker SO, Fiedler MO, Uhle F, Bauer M, Leonhardt J, Bloos F, Rummler S, Enghard P, Magomedov A, Zickler D, Kunz J, Dutzmann J, Vogt A, Girndt M, Markau S, Kochanek M, Naendrup JH, Zarbock A, Meersch M, von Groote T, Sadjadi M, Wempe C, Mitzner S, Heim M, Pilge S, Bubendorfer N, Schneider G, Lahmer T, Rasch S, Brenner T, Berger MM, Brands J, Espeter F, Freytag J, Kluge S, Jarczak D, Nierhaus A, Kielstein JT, Winkler M, Fühner T, Schmieszek J, Menne J, Sauer M, Richter G, Lautenschläger I, Radke D, Reising A, Keil A, Bramstedt J, Fahham M, Willam C, Herbst L, Bihlmaier K, Buettner C, Schellongowski P, Lobmeyr-Längle E, Sengölge G, Staudinger T, Schefold JC, Venetz P, Waskowski J, Pfortmueller CA, Joannidis M, Mayer G, Bellmann R, Koch A, Liu X:(2023)EXCHANGE-2: investigating the efficacy of add-on plasma exchange as an adjunctive strategy against septic shock-a study protocol for a randomized, prospective, multicenter, open-label, controlled, parallel-group trial.Trials. 2023;24(1):
Erb T, Mihai S, Strauß R, Herbst L, Castellanos I, Diesch K, Cipa F, Bihlmaier K, Lang A-K, Ganslmayer M, Willam C, Bremer F, Fürst J, Beyer C, Bogdan C, Rath A, Held J:(2023)β-(1→3)-D-glucan- and mannan-guided early termination of antifungal therapy in ICU patients: a randomized controlled study.Antimicrob Agents Chemother. 2023;67(11):
Hartner A, Dambietz T, Cordasic N, Willam C, Burzlaff N, Brötsch M, Daniel C, Schiffer M, Amann K, Veelken R, Schley G, Hilgers KF:(2023)No benefit of HIF prolyl hydroxylase inhibition for hypertensive renal damage in renovascular hypertensive rats.Front Physiol. 2023;14():
Gaupp C, Schmid B, Tripal P, Edwards A, Daniel C, Zimmermann S, Goppelt-Struebe M, Willam C, Rosen S, Schley G:(2023)Reconfiguration and loss of peritubular capillaries in chronic kidney disease.Sci Rep. 2023;13(1):
Willam C:(2023)[Adsorbers and their evidence].Anaesthesiologie. 2023;72(12): 841-842
Panchyrz I, Hoffmann J, Harst L, Pohl S, Bauer M, Blaschke S, Bodenstein M, Engelhart S, Gaertner B, Graf J, Hanses F, Held HC, Hinzmann D, Khan N, Kleber C, Kolibay F, Kubulus D, Liske S, Oberfeld J, Pletz MW, Prueckner S, Rohde G, Spinner CD, Stehr S, Willam C, Schmitt J:(2023)[Measures and Recommendations for Ensuring Adequate Inpatient Care Capacities for Pandemic Management within a Region: Results of a Hybrid Delphi Method].Gesundheitswesen. 2023;85(12): 1173-1182
Gerss J, Meersch M, Kindgen-Milles D, Brandenburger T, Willam C, Kellum JA, Zarbock A, RICH investigators:(2022)The Effect of Filter Lifespan during Continuous Renal Replacement Therapy in Critically Ill Patients with Acute Kidney Injury on the Rate of New-Onset Infection: Analysis from the RICH Randomized Controlled Trial.Am J Respir Crit Care Med. 2022;206(4): 511-514
Willam C, Meersch M, Herbst L, Heering P, Schmitz M, Oppert M, John S, Joerres A, Zarbock A, Janssens U, Kindgen-Milles D:(2022)Present practise patterns of renal replacement therapy in German intensive care medicine.Med Klin Intensivmed Notfmed. 2022;117(5): 367-373
John S, Riessen R, Karagiannidis C, Janssens U, Busch HJ, Kochanek M, Michels G, Hermes C, Buerke M, Kluge S, Baumgärtel M, Braune S, Erbguth F, Fuhrmann V, Lebiedz P, Mayer K, Müller-Werdan U, Oppert M, Sayk F, Sedding D, Willam C, Werdan K:(2021)[Core curriculum Medical intensive care medicine of the German Society of Medical Intensive Care and Emergency Medicine (DGIIN)].Med Klin Intensivmed Notfmed. 2021;116(Suppl 1): 1-45
Schley G, Willam C:(2021)["Intravascular space contracted-tissue space expanded": interstitial edema and fluid management in intensive care medicine].Med Klin Intensivmed Notfmed. 2021;116(8): 665-671
Kremer AE, Kremer AN, Willam C, Völkl S, Verhagen J, Achenbach S, van der Meijden ED, Lang V, Aigner M, Maier C, Tenbusch M, Korn K, Lutzny-Geier G, Spoerl S, Strauß R, Vetter M, Überla K, Neurath MF, Mackensen A, Schiffer M, Hackstein H:(2021)Successful treatment of COVID-19 infection with convalescent plasma in B-cell-depleted patients may promote cellular immunity.Eur J Immunol. 2021;51(10): 2478-2484
Fuchs MAA, Broeker KAE, Schrankl J, Burzlaff N, Willam C, Wagner C, Kurtz A:(2021)Inhibition of transforming growth factor β1 signaling in resident interstitial cells attenuates profibrotic gene expression and preserves erythropoietin production during experimental kidney fibrosis in mice.Kidney Int. 2021;100(1): 122-137
Willam C, Schley G:(2021)[Intravenous fluid therapy and acute kidney injury - What's new?]Dtsch Med Wochenschr. 2021;146(15): 977-981
Kluge S, Willam C:(2021)[Fluid management in emergency and intensive care medicine].Med Klin Intensivmed Notfmed. 2021;116(8): 635-635
Kuemmig T, Esse J, Herbst L, Castellanos I, Strauss R, Geissdoerfer W, Mihai S, Rakova N, Cipa F, Pflaum D, Werblow M, Lang AK, Bremer F, Ganslmayer M, Willam C, Held J:(2021)Is COVID-19-associated pulmonary aspergillosis (CAPA) a myth? Frequency of Aspergillus detection from respiratory samples in intensive care unit patients with and without COVID-19Mycoses. 2021;64 Suppl 1(): 3-3
Kindgen-Milles D, Heering P, Meersch-Dini M, Schmitz M, Oppert M, John S, Jörres A, Zarbock A, Willam C:(2020)[Quality improvement measures in the care of critically ill intensive care patients with renal replacement therapy for acute kidney injury : Position paper of the Kidney Section of DIVI in collaboration with DGAI and DGIIN].Med Klin Intensivmed Notfmed. 2020;115(7): 566-570
Bihlmaier K, Coras R, Willam C, Grampp S, Jabari S, Eichhorn P, Haller F, Kuramatsu J, Schwab S, Castellanos I, Birkholz T, Schüttler J, Altmeppen J, Schiffer M, Herbst L:(2020)Disseminated Multifocal Intracerebral Bleeding Events in Three Coronavirus Disease 2019 Patients on Extracorporeal Membrane Oxygenation As Rescue Therapy.Crit Care Explor. 2020;2(9):
Stockmann H, Keller T, Büttner S, Jörres A, Kindgen-Milles D, Kunz JV, Leebmann J, Spies C, Träger K, Treskatsch S, Uhrig A, Willam C, Enghard P, Slowinski T, CytoResc Trial Investigators:(2020)CytoResc - "CytoSorb" Rescue for critically ill patients undergoing the COVID-19 Cytokine Storm: A structured summary of a study protocol for a randomized controlled trial.Trials. 2020;21(1): 577
Mayer M, Fey K, Heinze E, Wick CR, Abboud MI, Yeh TL, Tumber A, Orth N, Schley G, Buchholz B, Clark T, Schofield CJ, Willam C, Burzlaff N:(2019)A Fluorescent Benzo[g]isoquinoline-Based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging.ChemMedChem. 2019;14(1): 94-99
Schley G, Klanke B, Kalucka J, Schatz V, Daniel C, Mayer M, Goppelt-Struebe M, Herrmann M, Thorsteinsdottir M, Palsson R, Beneke A, Katschinski DM, Burzlaff N, Eckardt KU, Weidemann A, Jantsch J, Willam C:(2019)Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis.Kidney Int. 2019;96(2): 378-396
Schley G, Jordan J, Ellmann S, Rosen S, Eckardt KU, Uder M, Willam C, Bäuerle T:(2019)Correction: Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology.PLoS ONE. 2019;14(6):
Schley G, Jordan J, Ellmann S, Rosen S, Eckardt KU, Uder M, Willam C, Bäuerle T:(2018)Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology.PLoS ONE. 2018;13(7):
Czock D, Schwenger V, Kindgen-Milles D, Joannidis M, John S, Schmitz M, Jörres A, Zarbock A, Oppert M, Kielstein JT, Willam C:(2018)[Dose adjustment of anti-infective drugs in patients with renal failure and renal replacement therapy in intensive care medicine : Recommendations from the renal section of the DGIIN, ÖGIAIN and DIVI].Med Klin Intensivmed Notfmed. 2018;113(5): 384-392
Schwenger V, Kindgen-Milles D, Willam C, Jörres A, Druml W, Czock D, Klein SJ, Oppert M, Schmitz M, Kielstein JT, Zarbock A, Joannidis M, John S:(2018)[Extracorporeal renal replacement therapy in acute kidney injury : Recommendations from the renal section of the DGIIN, ÖGIAIN and DIVI].Med Klin Intensivmed Notfmed. 2018;113(5): 370-376
Druml W, Joannidis M, John S, Jörres A, Schmitz M, Kielstein J, Kindgen-Milles D, Oppert M, Schwenger V, Willam C, Zarbock A:(2018)[Metabolic management and nutrition in critically ill patients with renal dysfunction : Recommendations from the renal section of the DGIIN, ÖGIAIN, and DIVI].Med Klin Intensivmed Notfmed. 2018;113(5): 393-400
Joannidis M, Klein SJ, John S, Schmitz M, Czock D, Druml W, Jörres A, Kindgen-Milles D, Kielstein JT, Oppert M, Schwenger V, Willam C, Zarbock A:(2018)[Prevention of acute kidney injury in critically ill patients : Recommendations from the renal section of the DGIIN, ÖGIAIN and DIVI].Med Klin Intensivmed Notfmed. 2018;113(5): 358-369
Schmitz M, Joannidis M, Czock D, John S, Jörres A, Klein SJ, Oppert M, Schwenger V, Kielstein J, Zarbock A, Kindgen-Milles D, Willam C:(2018)[Regional citrate anticoagulation in renal replacement therapy in the intensive care station : Recommendations from the renal section of the DGIIN, ÖGIAIN and DIVI].Med Klin Intensivmed Notfmed. 2018;113(5): 377-383
Kraus A, Peters DJM, Klanke B, Weidemann A, Willam C, Schley G, Kunzelmann K, Eckardt KU, Buchholz B:(2018)HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease.Kidney Int. 2018;94(5): 887-899
Schellinger IN, Cordasic N, Panesar J, Buchholz B, Jacobi J, Hartner A, Klanke B, Jakubiczka-Smorag J, Burzlaff N, Heinze E, Warnecke C, Raaz U, Willam C, Tsao PS, Eckardt KU, Amann K, Hilgers KF:(2017)Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease.Kidney Int. 2017;91(3): 616-627
Gerl K, Steppan D, Fuchs M, Wagner C, Willam C, Kurtz A, Kurt B:(2017)Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.Am J Pathol. 2017;187(7): 1496-1511
Gerl K, Nolan KA, Karger C, Fuchs M, Wenger RH, Stolt CC, Willam C, Kurtz A, Kurt B:(2016)Erythropoietin production by PDGFR-?(+) cells.Pflugers Arch. 2016;468(8): 1479-87
Ott C, Kistner I, Keller M, Friedrich S, Willam C, Bramlage P, Schmieder RE:(2016)Effects of linagliptin on renal endothelial function in patients with type 2 diabetes: a randomised clinical trial.Diabetologia. 2016;59(12): 2579-2587
Schatz V, Strüssmann Y, Mahnke A, Schley G, Waldner M, Ritter U, Wild J, Willam C, Dehne N, Brüne B, McNiff JM, Colegio OR, Bogdan C, Jantsch J:(2016)Myeloid Cell-Derived HIF-1? Promotes Control of Leishmania major.J Immunol. 2016;197(10): 4034-4041
Vogler M, Zieseniss A, Hesse AR, Levent E, Tiburcy M, Heinze E, Burzlaff N, Schley G, Eckardt KU, Willam C, Katschinski D:(2015)Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insultActa Physiol (Oxf). 2015;213 699(): 79-80
John S, Willam C:(2015)[Lung and kidney failure : Pathogenesis, interactions, and therapy].Med Klin Intensivmed Notfmed. 2015;110(6): 452-8
Kalucka J, Schley G, Georgescu A, Klanke B, Rössler S, Baumgartl J, Velden J, Amann K, Willam C, Johnson RS, Eckardt KU, Weidemann A:(2015)Kidney injury is independent of endothelial HIF-1?.J Mol Med. 2015;93(8): 891-904
Vogler M, Zieseniss A, Hesse AR, Levent E, Tiburcy M, Heinze E, Burzlaff N, Schley G, Eckardt KU, Willam C, Katschinski DM:(2015)Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult.Pflugers Arch. 2015;467(10): 2141-9
Zacharias HU, Hochrein J, Vogl FC, Schley G, Mayer F, Jeleazcov C, Eckardt KU, Willam C, Oefner PJ, Gronwald W:(2015)Identification of Plasma Metabolites Prognostic of Acute Kidney Injury after Cardiac Surgery with Cardiopulmonary Bypass.J Proteome Res. 2015;14(7): 2897-905
Schley G, Scholz H, Kraus A, Hackenbeck T, Klanke B, Willam C, Wiesener MS, Heinze E, Burzlaff N, Eckardt KU, Buchholz B:(2015)Hypoxia inhibits nephrogenesis through paracrine Vegfa despite the ability to enhance tubulogenesis.Kidney Int. 2015;88(6): 1283-1292
Schley G, Köberle C, Manuilova E, Rutz S, Forster C, Weyand M, Formentini I, Kientsch-Engel R, Eckardt KU, Willam C:(2015)Comparison of Plasma and Urine Biomarker Performance in Acute Kidney Injury.PLoS ONE. 2015;10(12): e0145042
Siegert I, Schödel J, Nairz M, Schatz V, Dettmer K, Dick C, Kalucka J, Franke K, Ehrenschwender M, Schley G, Beneke A, Sutter J, Moll M, Hellerbrand C, Wielockx B, Katschinski DM, Lang R, Galy B, Hentze MW, Koivunen P, Oefner PJ, Bogdan C, Weiss G, Willam C, Jantsch J:(2015)Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1? upon LPS Activation in the Presence of Ample Oxygen.Cell Rep. 2015;13(10): 2048-55
Schulz K, Hagos Y, Burckhardt G, Schley G, Burzlaff N, Willam C, Burckhardt BC:(2015)The Isoquinolone Derived Prolyl Hydroxylase Inhibitor ICA Is a Potent Substrate of the Organic Anion Transporters 1 and 3.Nephron. 2015;131(4): 285-9
Tian W, Wang Y, Xu Y, Guo X, Wang B, Sun L, Liu L, Cui F, Zhuang Q, Bao X, Schley G, Chung TL, Laslett AL, Willam C, Qin B, Maxwell PH, Esteban MA:(2014)The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity.J Biol Chem. 2014;289(6): 3339-51
Willam C:(2014)HIF meets NF-?B signaling.Kidney Int. 2014;85(2): 232-4
Buchholz B, Schley G, Faria D, Kroening S, Willam C, Schreiber R, Klanke B, Burzlaff N, Jantsch J, Kunzelmann K, Eckardt KU:(2014)Hypoxia-Inducible Factor-1? Causes Renal Cyst Expansion through Calcium-Activated Chloride Secretion.J Am Soc Nephrol. 2014;25(3): 465-74
Singh RP, Franke K, Kalucka J, Mamlouk S, Muschter A, Gembarska A, Grinenko T, Willam C, Naumann R, Anastassiadis K, Stewart AF, Bornstein S, Chavakis T, Breier G, Waskow C, Wielockx B:(2013)HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.Blood. 2013;121(26): 5158-66
Kurt B, Paliege A, Willam C, Schwarzensteiner I, Schucht K, Neymeyer H, Sequeira-Lopez ML, Bachmann S, Gomez RA, Eckardt KU, Kurtz A:(2013)Deletion of von Hippel-Lindau protein converts renin-producing cells into erythropoietin-producing cells.J Am Soc Nephrol. 2013;24(3): 433-44
Forster C, Schriewer J, John S, Eckardt KU, Willam C:(2013)Low-flow CO2 removal integrated into a renal-replacement circuit can reduce acidosis and decrease vasopressor requirements.Crit Care. 2013;17(4): R154
Schley G, Klanke B, Schödel J, Kröning S, Türkoglu G, Beyer A, Hagos Y, Amann K, Burckhardt BC, Burzlaff N, Eckardt KU, Willam C:(2012)Selective stabilization of HIF-1? in renal tubular cells by 2-oxoglutarate analogues.Am J Pathol. 2012;181(5): 1595-606
Wang Z, Schley G, Türkoglu G, Burzlaff N, Amann KU, Willam C, Eckardt KU, Bernhardt WM:(2012)The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment.Nephrol Dial Transplant. 2012;27(3): 929-36
Schietke RE, Hackenbeck T, Tran M, Günther R, Klanke B, Warnecke CL, Knaup KX, Shukla D, Rosenberger C, Koesters R, Bachmann S, Betz P, Schley G, Schödel J, Willam C, Winkler T, Amann K, Eckardt KU, Maxwell P, Wiesener MS:(2012)Renal Tubular HIF-2? Expression Requires VHL Inactivation and Causes Fibrosis and Cysts.PLoS ONE. 2012;7(1): e31034
Tian YM, Yeoh KK, Lee MK, Eriksson T, Kessler BM, Kramer HB, Edelmann MJ, Willam C, Pugh CW, Schofield CJ, Ratcliffe PJ:(2011)Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.J Biol Chem. 2011;286(15): 13041-51
Strehl JD, Brandenburg V, Forster C, Willam C, Hartmann A, Amann K:(2011)[Calciphylaxis : A less well-known, clinically relevant disease.]Pathologe. 2011;32(3): 250-256
Jantsch J, Wiese M, Schödel J, Castiglione K, Gläsner J, Kolbe S, Mole D, Schleicher U, Eckardt KU, Hensel M, Lang R, Bogdan C, Schnare M, Willam C:(2011)Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1? (HIF1A) and result in differential HIF1A-dependent gene expression.J Leukoc Biol. 2011;90(3): 551-62
Schley G, Klanke B, Schödel J, Forstreuter F, Shukla D, Kurtz A, Amann K, Wiesener MS, Rosen S, Eckardt KU, Maxwell PH, Willam C:(2011)Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury.J Am Soc Nephrol. 2011;22(11): 2004-15
Schödel J, Bohr D, Klanke B, Schley G, Schlotzer-Schrehardt U, Warnecke C, Kurtz A, Amann K, Eckardt KU, Willam C:(2010)Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells.Kidney Int. 2010;78(9): 857-67
Hackenbeck T, Knaup KX, Schietke R, Schödel J, Willam C, Wu X, Warnecke C, Eckardt KU, Wiesener MS:(2009)HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia.Cell Cycle. 2009;8(9): 1386-95
Schödel J, Klanke B, Weidemann A, Buchholz B, Bernhardt W, Bertog M, Amann K, Korbmacher C, Wiesener M, Warnecke C, Kurtz A, Eckardt KU, Willam C:(2009)HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury.Am J Pathol. 2009;174(5): 1663-74
Bernhardt WM, Gottmann U, Doyon F, Buchholz B, Câmpean V, Schödel J, Reisenbuechler A, Klaus S, Arend M, Flippin L, Willam C, Wiesener MS, Yard B, Warnecke C, Eckardt KU:(2009)Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model.Proc Natl Acad Sci U S A. 2009;106(50): 21276-81
Weidemann A, Bernhardt WM, Klanke B, Daniel C, Buchholz B, Câmpean V, Amann K, Warnecke C, Wiesener MS, Eckardt KU, Willam C:(2008)HIF activation protects from acute kidney injury.J Am Soc Nephrol. 2008;19(3): 486-94
Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P:(2008)Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.Nat Genet. 2008;40(2): 170-80
Jantsch J, Chakravortty D, Turza N, Prechtel AT, Buchholz B, Gerlach RG, Volke M, Gläsner J, Warnecke C, Wiesener MS, Eckardt KU, Steinkasserer A, Hensel M, Willam C:(2008)Hypoxia and Hypoxia-Inducible Factor-1{alpha} Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function.J Immunol. 2008;180(7): 4697-705
Warnecke C, Weidemann A, Volke M, Schietke R, Wu X, Knaup KX, Hackenbeck T, Bernhardt W, Willam C, Eckardt KU, Wiesener MS:(2008)The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors.Exp Cell Res. 2008;314(10): 2016-27
Jantsch J, Turza N, Volke M, Eckardt KU, Hensel M, Steinkasserer A, Willam C, Prechtel AT:(2008)Small interfering RNA (siRNA) delivery into murine bone marrow-derived dendritic cells by electroporation.J Immunol Methods. 2008;337(1): 71-77
Weidemann A, Klanke B, Wagner M, Volk T, Willam C, Wiesener MS, Eckardt KU, Warnecke C:(2008)Hypoxia, via stabilization of the hypoxia-inducible factor HIF-1alpha, is a direct and sufficient stimulus for brain-type natriuretic peptide induction.Biochem J. 2008;409(1): 233-42
Bernhardt WM, Wiesener MS, Weidemann A, Schmitt R, Weichert W, Lechler P, Câmpean V, Ong AC, Willam C, Gretz N, Eckardt KU:(2007)Involvement of hypoxia-inducible transcription factors in polycystic kidney disease.Am J Pathol. 2007;170(3): 830-42
Eckardt KU, Bernhardt W, Willam C, Wiesener M:(2007)Hypoxia-inducible transcription factors and their role in renal disease.Semin Nephrol. 2007;27(3): 363-72
Hohenstein B, Uder M, Willam C, Amann KU, Eckardt KU, Hugo CP:(2007)Transvenous renal biopsy of a kidney transplant in a patient with a suspected bleeding disorder.Am J Transplant. 2007;7(8): 2052-3
Wiesener MS, Münchenhagen P, Glaser M, Sobottka BA, Knaup KX, Jozefowski K, Jürgensen JS, Roigas J, Warnecke C, Gröne HJ, Maxwell PH, Willam C, Eckardt KU:(2007)Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia.Int J Cancer. 2007;121(11): 2434-42
Lechler P, Wu X, Bernhardt W, Câmpean V, Gastiger S, Hackenbeck T, Klanke B, Weidemann A, Warnecke C, Amann K, Engehausen D, Willam C, Eckardt KU, Rödel F, Wiesener MS:(2007)The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney.Am J Pathol. 2007;171(5): 1483-98
Bernhardt WM, Warnecke C, Willam C, Tanaka T, Wiesener MS, Eckardt KU:(2007)Organ protection by hypoxia and hypoxia-inducible factors.Methods Enzymol. 2007;435(): 219-45
Willam C, Warnecke C, Schefold JC, Kügler J, Koehne P, Frei U, Wiesener M, Eckardt KU:(2006)Inconsistent effects of acidosis on HIF-alpha protein and its target genes.Pflugers Arch. 2006;451(4): 534-43
Bernhardt WM, Câmpean V, Kany S, Jürgensen JS, Weidemann A, Warnecke C, Arend M, Klaus S, Günzler V, Amann K, Willam C, Wiesener MS, Eckardt KU:(2006)Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure.J Am Soc Nephrol. 2006;17(7): 1970-8
Willam C, Maxwell PH, Nichols L, Lygate C, Tian YM, Bernhardt W, Wiesener M, Ratcliffe PJ, Eckardt KU, Pugh CW:(2006)HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.J Mol Cell Cardiol. 2006;41(1): 68-77
Bernhardt WM, Schmitt R, Rosenberger C, Münchenhagen PM, Gröne HJ, Frei U, Warnecke C, Bachmann S, Wiesener MS, Willam C, Eckardt KU:(2006)Expression of hypoxia-inducible transcription factors in developing human and rat kidneys.Kidney Int. 2006;69(1): 114-22
Eckardt KU, Bernhardt WM, Weidemann A, Warnecke C, Rosenberger C, Wiesener MS, Willam C:(2005)Role of hypoxia in the pathogenesis of renal diseaseKidney Int. 2005;68 Suppl. (): 46-51
Eckardt KU, Bernhardt WM, Weidemann A, Warnecke C, Rosenberger C, Wiesener MS, Willam C:(2005)Role of hypoxia in the pathogenesis of renal disease.Kidney Int Suppl. 2005;(99): S46-51
Bernhardt WM, Kany S, Câmpean V, Jürgensen JS, Weidemann A, Warnecke C, Willam C, Frei U, Amann K, Wiesener MS, Eckardt KU:(2005)Preconditional induction of HIF by carbon monoxide ameliorates ischemic acute renal failureNephrol Dial Transplant. 2005;20 Suppl.(): V54-V54
Warnecke C, Griethe W, Weidemann A, Jürgensen JS, Willam C, Bachmann S, Ivashchenko Y, Wagner I, Frei U, Wiesener M, Eckardt KU:(2003)Activation of the hypoxia-inducible factor-pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors.FASEB J. 2003;17(9): 1186-8
Willam C, Masson N, Tian YM, Mahmood SA, Wilson MI, Bicknell R, Eckardt KU, Maxwell PH, Ratcliffe PJ, Pugh CW:(2002)Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis.Proc Natl Acad Sci U S A. 2002;99(16): 10423-8